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KMID : 0355620210470020076
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Journal of Korean Association of Oral and Maxillofacial Surgeons
2021 Volume.47 No. 2 p.76 ~ p.81
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Primary malignant mucosal melanoma of the maxillofacial area
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Kim Hyoun-Min
Lee Sang-Hoon
Cha In-Ho
Kim Hyung-Jun
Nam Woong
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Abstract
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Objectives: We aimed to collect and report data from all patients who have been diagnosed with mucosal malignant melanoma to obtain the epidemiology and principles of current treatments.
Materials and Methods: Between January 2008 and December 2018, 20 patients underwent surgery or follow-up observations at Yonsei University Dental Hospital. The patients’ clinical information was reviewed retrospectively.
Results: Seventeen of 20 patients had undergone definitive surgery, while only 6 patients received adjuvant radiotherapy or systemic therapy. Eight of 20 patients, including those that had recurrent lesions, were provided immunotherapy. The 3-year survival for all stages was 50%, with a local recurrence rate of 75% and a metastasis rate of 65%.
Conclusion: The overall survival of patients receiving surgical treatment was longer than that of patients who did not undergo surgical resection. Eight of 20 patients received immunotherapy as the first-line regimen at our clinic, and those patients exhibited longer overall survival compared to patients in reported keynote studies.
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KEYWORD
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Malignant melanoma, Immunotherapy, Oral cancer
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